Heading into Week 16, the Buffalo Bills had taken over as the favorites to win Super Bowl LIX with +425 odds. Their quarterback, Josh Allen, had also solidified himself as the MVP frontrunner. But the results of Saturday's games served as a reminder that there are no sure things in the NFL.

Allen is playing the best football of his career, with 36 combined touchdowns and only seven turnovers for the AFC East champions.

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Buffalo has the best odds in the NFL. The Bills (11-3) currently sits second in the AFC playoff picture. The Kansas City Chiefs remain atop the playoff standings, two games ahead of the Bills. However,

Buffalo Bills top Fanduel at +450, trailed by Eagles, Chiefs, Lions at 5:1. Check team rankings and stats. Joe Lisi joins the show to break down the market.