Mitochondria are the body's "energy factories," and their proper function is essential for life. Inside mitochondria, a set ...

Researchers at Tohoku University have discovered that an oral drug called MA-5 can improve both heart and muscle problems in ...

Researchers at Tohoku University have discovered that an oral drug called MA-5 can improve both heart and muscle problems in ...

Given the amino-acid sequence or 3D structure of a protein, how much can we predict about its function using just a desktop computer? The recent explosive growth in the volume of sequence data and ...

Pharmacophore modeling of a series of aldosterone synthase (CYP11B2) inhibitors triggered the design of compounds 11 and 12 by extending a previously established naphthalene molecular scaffold (e.g., ...

Abstract The mitochondrial F 1 F 0 -ATP synthase is crucial for maintaining the ATP/ADP balance which is critical for cell metabolism, ion homeostasis and cell proliferation. This enzyme, conserved ...

Self-assembled peptides are promising templates for the design of inhibitors of protein–protein interactions (PPIs) because they can be endowed with affinity- and selectivity-defining amino acids ...