This article is part of a series on viroids. The first, which can be read here, gave an overview of what viroids are and how they replicate. The second article described the plant host range of ...

The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...

RNAi is mediated by the enzymatic processing of long double-stranded RNA (dsRNA) into short-interfering RNA (siRNA)with sequence homology to the target mRNA. These siRNA molecules associate with a ...

This article is part 2 of a series on next-generation mRNA vaccines. The first installment can be read here. The unprecedented speed with which we developed vaccines to help us control and curb the ...

The first reports of antisense RNA activity in eukaryotes were published when the efforts to understand the mechanism of mRNA translation were well underway. At that time, cell-free in vitro ...

The discovery of siRNA and its role in RNAi was a groundbreaking finding in the field of molecular biology. In 1998, Andrew Fire and Craig Mello published a seminal paper describing the phenomenon of ...

RNA interference (RNAi) is a key biological process that leads to the silencing of gene expression. RNAi can be initiated by a cell in response to pathogenic nucleic acids to bring about a targeted ...

Lipoprotein(a) is a presumed risk factor for atherosclerotic cardiovascular disease. Olpasiran is a small interfering RNA that reduces lipoprotein(a) synthesis in the liver. We conducted a randomized, ...

For the first time, a drug to treat adult patients with familial chylomicronemia syndrome (FCS), a severe and rare condition that leads to extremely high levels of blood fats called triglycerides, has ...