This study, led by Dr. Panpan Jiang and collaborators at Tongji Medical College, explores the critical role of the Dedicator of Cytokinesis 8 (DOCK8) gene in the differentiation of helper T cells, ...

In the last part of my talk, I'm going to describe three examples of novel therapeutic approaches for the prevention and treatment of diabetic complications, all based on the new paradigm of a ...

The authors aim to understand why Kupffer cells (KCs) die in metabolic-associated steatotic liver disease (MASLD). This is a useful study using in vitro studies and an in vivo genetic mouse model, ...

Distinct glycolysis-related molecular subtypes in GC were identified using TCGA and GEO datasets. CLDN9 was identified as a key gene associated with the glycolytic subtype and prognosis of GC. CLDN9 ...

The pentose phosphate pathway takes place exclusively in the cytosol of the cell. The cytosol, also known as the cytoplasmic matrix, is the intracellular fluid that surrounds all the organelles within ...

Aerobic glycolysis, the process by which cells transform glucose into lactate, is key for eye development in mammals, according to a new Northwestern Medicine study published in Nature Communications.

Yale researchers are sifting through a mosaic of cells in a living animal—both normal cells and mutated cells—to better ...

Diabetes induced vascular disease is an important cause of blindness, renal failure, and nerve damage. Four major signaling pathways have been implicated in this vascular damage, three of which are ...

The immune system is continually surveilling the body—looking for pathogens, xenobiotics, and other non-self signals. The various cell types which constitute the immune system are, thus, incredibly ...

Glycolysis-dependent Sulfur Metabolism Orchestrates Morphological Transitions and Virulence in Fungi.