PTEN is a tumor suppressor protein with potential therapeutic applications in cancer treatment. The research aims to explore the efficacy of CNTs as a delivery system for PTEN variants and assess ...
In a new study published in the New England Journal of Medicine, researchers led by Charis Eng, MD, PhD and Pier Paolo Pandolfi, MD, PhD, FRCP determined that mutations of the WWP1 gene may also drive ...
Association between prostate radiation therapy and survival among patients with metastatic prostate cancer by extent of disease burden. This is an ASCO Meeting Abstract from the 2025 ASCO Annual ...
A collaboration between Saïd M. Sebti, Ph.D., chair of Moffitt Cancer Center's Drug Discovery Department, and Michele Pagano, M.D., chair of the Department of Biochemistry and Molecular Pharmacology ...
Phosphatases have many important functions within the cell, but little has been known about the roles these proteins play in tumor suppression. In September Development, Gang Li and colleagues from ...
Genetic alterations targeting the PTEN tumor suppressor gene are among the most frequently noted somatic mutations in human cancers. Such lesions have been noted in cancers of the prostate and ...
A study published in Science Advances reveals a novel strategy that allows tumors to evade the body's immune response critical for their elimination. Researchers at Baylor College of Medicine and ...
Bella Grambau has been told she is the only person in Australia and one of only a handful of people in the world with a rare ...
A lipid-rich and hypoxia tumor microenvironment elevates O-GlcNAc transferase (OGT) expression, catalyzing O-GlcNAcylation of the tumor suppressor PTEN. Specifically, O-GlcNAcylation of PTEN in T382 ...
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