Nature

A PML1-CCL5-PI3K/MAPK feedback loop governs survival of endocrine-resistant breast cancer cells

The mechanisms that mediate endocrine therapy resistance remain incompletely understood. We identified promyelocytic leukemia protein isoform 1 (PML1) as a central node of this resistance. We ...
Nature

Calcium-Sensing Receptor Mechanisms in Endocrine Signaling

The calcium-sensing receptor (CaSR) is a class C G-protein-coupled receptor that serves as a central regulator of extracellular calcium homeostasis by modulating parathyroid hormone (PTH) secretion ...
ascopubs.org

Molecular profiling after short-term preoperative endocrine therapy to identify oestrogen receptor positive (ER+)/HER2+ early breast tumours with favourable prognosis.

Association of circulating T lymphocytes and their functional states with pathologic complete response (pCR) in breast cancer (BC). A prospective Italian study. This is an ASCO Meeting Abstract from ...
Cure Today

How Endocrine Therapy Works in ER-Positive, HER2-Negative Metastatic Breast Cancer

In this segment, Dr. Gregory Vidal explains how hormone, or endocrine, therapies work to slow or stop cancer growth in ER-positive, HER2-negative metastatic breast cancer. In this segment, Dr. Gregory ...