Researchers have identified a molecular brake that limits DNA replication in healthy cells, revealing how cells prevent a long-suspected replication catastrophe and pointing to a potential ...

Six feet of DNA crammed into a cell nucleus narrower than a human hair: Life may pack no tighter puzzle than this. And yet, biology pulls it off every second, compressing genetic material with a ...

Inside human cells, biology has pulled off the ultimate packing job, figuring out how to fit six feet of DNA into a nucleus about one-tenth as wide as a human hair while making sure the all-important ...

New research led by researchers at the University of California, San Diego (UCSD), School of Medicine, reveals a novel map that depicts the human body’s system for addressing and repairing DNA ...

One of the most detailed 3D maps of how the human chromosomes are organized and folded within a cell's nucleus is published in Nature. Chromosomes are thread-like structures that carry a cell's ...

In its effort to correlate genomic structure with gene function, the 4D Nucleome Consortium (4DN), led by Job Dekker, PhD, at UMass Chan Medical School, has extensively mapped and analyzed the ...

A team of researchers led by HHMI Investigator Michael Rosen has captured the most detailed images yet of the molecules in synthetic chromatin condensates — droplet-like structures of compacted DNA.