Wilson Bethel made his supervillain debut in Daredevil season 3, which was not set in the MCU. Benjamin "Dex" Poindexter, later known as Bullseye, became one of the show’s most iconic antagonists.
Mole is the super villain of Fantastic Four in the comics and is set to make his debut in The Fantastic Four: First Steps.
That would be shift from the comics, in which Karen dies at the hands of Bullseye. Given that Bullseye appears in the trailer only in handcuffs, it seems like the series is saving him for a later ...