The Cleveland Browns could stun the rest of the NFL with a surprising trade sending Shedeur Sanders to the NFC.

Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2025 NFL Week 6 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

USA TODAY Sports' latest 2026 NFL mock draft features a major shift at the top, with QBs Fernando Mendoza and Dante Moore battling it out for No. 1.

The 49ers (4-1) travel across the country to face the Bucs (4-1), and both teams are coming off entertaining 3-point wins on the road. The 49ers — despite being riddled with injuries on offense — won Thursday night over the Rams as huge underdogs. Mac Jones filled in again for quarterback Brock Purdy and the 49ers offense looked good.

New York Giants coach Brian Daboll apologized after shouting at the team doctor during Jaxson Dart’s concussion exam. The NFL said the incident is under review.

All of this went down a week after the Giants embarrassed themselves in a 26-14 defeat at the previously winless New Orleans Saints in Week 5. Given the unthinkable kicked off Week 6 in the NFL, pretty much anything could happen in the rest of this week's action.

The New York Giants' handling of rookie quarterback Jaxson Dart's concussion evaluation during Thursday night's 34-17 win over the Philadelphia Eagles is currently under review by the NFL.

Dallas Cowboys owner Jerry Jones is still facing a major decision regarding his recent punishment from the NFL.

Not that the league had any potential liability arising from Kendrick Lamar’s performance during the Super Bowl halftime show of “Not Like Us,” with lyrics that dub Lamar’s rival, Drake, as a “certified pedophile.” But the NFL won’t have to spend any time, effort, or money preparing and presenting witnesses during discovery or at trial.

Former Arizona Cardinals linebacker Wesley Leasy was mistakenly detained at Phoenix Sky Harbor Airport in April.

If you don't believe in your current quarterback, Saturday's Fernando Mendoza (Indiana) vs. Dante Moore (Oregon) showdown is a must-watch.