Neillsville is a city and county seat of Clark County, Wisconsin, United States. The population was 2,384 at the 2020 census. The Ojibwa were the earliest known residents of the Neillsville area. The first settlers of European descent in the area were James O'Neill and his party, who arrived around 1845, looking for a location to build a sawmill along the Black River. The city was named in honor of O'Neill, as was O'Neill Creek, which runs through the center of the city and drains into the Black River.
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